Rojo Duro Red Onion Extract Loaded Spray Thermogel as a Sustainable Platform for the Treatment of Oral Mucosa Lesions

The urgent need for new green and sustainable models is ground the current demand of innovative renewable resource based pharmaceutical products. We propose a Rojo Duro skin onion extract loaded poloxamer/chitosan spray mucoadhesive thermogel aimed at solving limitations in oral mucosits treatment. Being among main side effects radio- chemotherapy, effective treatment buccal lesions still represents an unmet medical need. obtained combined optimal gelling capacity, release behavior, sprayability, mucoadhesion properties, while maintaining antioxidant antimicrobial properties. product preserved all properties when stored 1 month as freeze-dried powder 4 °C. This potential highly translational, it combines recognized safety to administration/application advantages, well simplicity sustainability.